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InformationMouse Soluble Alpha Klotho ELISA Kit (18.06 pg/ml sensitivity, a-klotho, alpha klotho; Part 27601, 96T)
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Introduction
Membrane bound Klotho is 130kDa type-I membrane protein that is related to β-glucuronidases. It has been implicated in calcium and phosphorus regulation. Shedding of the ectodomain results in the generation of 70kDa soluble alpha-klotho. Reduced production of klotho has been observed in human with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing, bone loss and alcohol consumption. Transgenic mice that overexpress Klotho live longer than wild-type mice. Klotho has been characterized as modulating amyloid beta pathogenesis in Alzheimers disease in humans.
Format: Sandwich ELISA Kit, 96T, strip plate, HRP detection
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Product Code
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27601
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Product Name
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Mouse soluble α-Klotho Assay Kit - IBL
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Maker Name
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Immuno-Biological Laboratories Co., Ltd.
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Intended Use
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Research reagents
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Measuring Method
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ELISA
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Conjugate
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HRP
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Species
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Mouse
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Measuring Samples
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Urine
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Measurement Range
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78.13 ～ 5000 pg/mL
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Primary Reaction
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60 minutes at 37 ℃
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Secondary Reaction
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30 minutes at 2 - 8 ℃
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Sensitivity
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18.06 pg/mL
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Specificity
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Mouse soluble α-Klotho 100%
Mouse soluble α-Klotho(KL1) 100% Mouse soluble β-Klotho ≦0.1% Human soluble α-Klotho ≦0.1% Rat soluble α-Klotho N.T |
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Storage Condition
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2 - 8 ℃
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Protocol
Overview Pamphlet
A control set is available: please inquire
Shipping: Domestic and international delivery available.
