Human Soluble α-Klotho ELISA Kit (alpha-klotho, alpha klotho, 96T; 27998)

Human Soluble Alpha Klotho ELISA Kit

Introduction

Membrane bound Klotho is type-I membrane protein that is related to β-glucuronidases.  Shedding of the ectodomain results in the generation of soluble alpha-klotho.  Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF.  Also, mutations within this protein have been associated with ageing, bone loss and alcohol consumption.  Transgenic mice that overexpress Klotho live longer than wild-type mice.  Klotho has been characterized as modulating amyloid beta pathogenesis in Alzheimers disease. 

Updated:  11-18-2019

Format:  Sandwich ELISA Kit, 96T, Strip Plate, HRP detection

HRP