LEPTIN ELISA KITS (96T: Human # 27775, Mouse # 27160, Rat # 27160)

Here's a breakdown of what leptin does:

• Appetite Regulation: Leptin's main function is to communicate to the brain, particularly the hypothalamus, the amount of energy stored as fat. Higher leptin levels signal sufficient energy stores, leading to a decrease in hunger and food intake. Conversely, lower leptin levels signal low energy reserves, stimulating appetite.  
   

   
• Energy Expenditure: Besides reducing hunger, leptin can also signal the body to increase energy expenditure (calorie burning).  
   
• Long-Term Weight Maintenance: Leptin helps the body maintain a stable weight over time by balancing food intake and energy use.  
   
• Other Physiological Processes: Research suggests leptin is also involved in other bodily functions, including metabolism, endocrine regulation, immune function, energy homeostasis, and reproductive function.  
   

Leptin Levels:

The amount of leptin in the bloodstream is directly proportional to the amount of body fat. Generally:  

• Higher body fat leads to higher leptin levels.  
   
• Lower body fat leads to lower leptin levels.  
   

Leptin Resistance:

In some individuals, particularly those with obesity, a condition known as leptin resistance can develop. In this state, the brain doesn't respond effectively to leptin's signals, even when leptin levels are high due to increased fat stores.  

• Increased Hunger: The brain doesn't receive the "full" signal, leading to persistent hunger and increased food intake.  
   
• Reduced Metabolism: The body may enter a "starvation mode," conserving energy and burning fewer calories.
• Weight Gain: Despite having ample energy stores, the body continues to crave food and store fat, contributing to weight gain and difficulty losing weight.

In summary, leptin is a vital hormone that helps regulate energy balance in the body. While it plays a key role in signaling satiety, the development of leptin resistance can disrupt this process and contribute to obesity