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Protein Crystallization (PCS-1)

Protein Crystallization (PCS-1)
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Model: PCS-1
Manufacturer: International University Line

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Protein Crystallization (PCS-1)
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The third edition includes three new chapters. Janet Newman has written on optimization of crystallization hits (Chapter 18) as a follow-up to her earlier chapter on screening (Chapter 15). Martin Caffrey describes state-of-the art methods for membrane protein crystallization (Chapter 19), and Soneya Majumdar the preparation and crystallization of macromolecular complexes (Chapter 20). The A-Z section is revised and expanded in this edition. It is a repository for short topics, 80% of them new for this edition. Finally, five “how to” protocols are included. The reader may also notice there are more color figures and images. Color is easier to include in e-books, so this third edition reflects that.

This edition, like the first two (published in 1999 and 2010), is intended to be a practical guide for the person in the wet lab. As editor, I aimed to provide an overview of topics, assure cohesion between the chapters and sections of the book, and to guide the reader to related topics in other chapters. Overlap of topics is intentional for the readers who are not reading the book cover to cover. Written by the best experts in protein crystallization from different countries.

Edited by Terese M. Bergfors, Dept. of Molecular Biology, Uppsala University, Sweden.

Obtaining good quality protein crystals still remains a bottleneck in structural determination by X-ray crystallography. This book is written for biochemists, crystallographers, graduate students, technicians, undergraduates or anyone else working with proteins with the intention of crystallizing them. The approach discussed in Protein Crystallization is a practical one and no previous experience of the laboratory techniques is assumed. Protein Crystallization is suitable for beginners in the field, but the extent of the material provides a thorough coverage of the topic for experienced structural biologists.  Laboratory exercises are included which can be used for teaching purposes in protein crystallization or crystallography courses. The exercises have been tested in the "Practical Protein Crystallization" courses that have been running since 1994 at Uppsala University (Sweden), as well as courses elsewhere.
 
Protein Crystallization is divided into four separate sections: Methods, Tools and Strategies, Laboratory Exercises, and an A-Z Glossary. There are 30 color plates for identifying phenomena found in crystallization drops. As in the first edition, the emphasis of the book is on practical problems and questions encountered at the lab bench.

Book Details:  Protein Crystallization

  • Publisher ‏ : ‎ International University Line; 3rd edition (April 18, 2022)
  • Language ‏ : ‎ English
  • Paperback ‏ : ‎ 670 pages
  • ISBN-10 ‏ : ‎ 0972077464
  • ISBN-13 ‏ : ‎ 978-0972077460
  • Item Weight ‏ : ‎ 3.11 pounds

To view Preface, please click button  

To view Table of Contents, please click button  



Editorial Reviews
"This is an essential handbook for anyone engaged in crystallization of macromolecules. It is exceptionally well organized and illustrated and has contributions from all the leaders in what continues to be a challenging and critically important field." --Dr. William L. Duax, American Crystallographic Association, Executive Officer

"Why is crystallization important? At different times, different aspects of protein crystallography have assumed the role of bottleneck. Thus at one time the bottleneck consisted of the lack of a methodology for structure determination, even if a sufficient number of diffraction intensitities were available for structure solution. With the advent of powerful methods for structure solution, the bottleneck shifted to the difficulty in obtaining crystals in sufficient number and of suitable quality to do the diffraction experiment. The present book is dedicated to the problem of describing current methods for protein crystallization and describing them as clear laboratory protocols." --Dr. Herbert A. Hauptman, 1985 Nobel Laureate in Chemistry 

"I used the first edition as a graduate student. It was a perfect guide for protein crystallizers at all stages of their careers, providing methodical, clear explanations in lay terminology." --Dr. Lata Govada, Imperial College London

 



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